REJEON PCL Filler Txhaj Tshuaj Tiv Thaiv-wrinkle lifting thiab firming
Keeb kwm ntawm REJEON PCL
Hauv 20 xyoo dhau los, peb txoj kev nkag siab ntawm ib qho ntawm cov cheeb tsam nyuaj tshaj plaws ntawm tib neeg lub cev - lub ntsej muag - tau txhim kho zoo heev, nrog rau ntau yam qauv anatomical tshiab tau txheeb xyuas.
Nyob rau tib lub sijhawm, muaj ntau yam uas tsis yog phais
cov txheej txheem tau dhau los ua kev kho mob
cov cim ntawm kev laus thiab kho cov hluas
lub ntsej muag. REJEON yog thawj, thiab
Tam sim no tsuas yog, collagen sti mulator uas yog ua los ntawm polycaprolactone microspheres, uas pab txhawb rau nws cov kev ua kom zoo nkauj ruaj khov. REJEON
Cov khoom tshwj xeeb txhais tau hais tias nws yog qhov xav tau kev xaiv rau ntau cov txheej txheem ntawm cov ntaub so ntswg.
Cov ntsiab lus
Cov ntsiab lus ntawm REJ EO N,
70% aqueous CMC-raws li
gel nqathiab30% PCL
muaj pes tsawg leeg,tso cai rau
ib qho tam sim filling nyhuv
tshwm sim los ntawm CMC, ua raws li stimulation ntawm lub cev tus kheej collagen (neocollagenesis).
CMC yog resorbed 2 mus rau 3
hli tom qab txhaj tshuajthiab hloov zuj zus los ntawm tus neeg mob tus kheej
collagen (feem ntau hom I) stimulated los ntawm
PCL microspheres. Cov microspheres ntawm PCL kuj tseem bioresorbable.
REJEON muaj ntau tus cwj pwm uas ua rau nws qhov kev xaiv zoo nkauj raws li cov khoom siv dermal:
①Encapsulation ntawm polymer microspheres, nyob rau hauv kwv yees li 1 lub hlis, thiab cov cuam tshuam collagen scaffold tiv thaiv ntxiv inflammatory tshwm sim los ntawm tshwm sim13
②Cov hom collagen uas muaj hnub nyoog nyob rau hauv qhov chaw txhaj tshuaj yog feem ntau yog ' mature' collagen scaffold ntawm collagen hom I5
a) Qhov txo qis ntawm collagen hom III txhais tau tias tsis muaj kev txhawb nqa ntxiv ntawm cov lus teb inflammatory
③ Lub degradation ntawm REJEON constituents yog ua tiav los ntawm hydrolysis, cia li dej thiab carbon dioxide.
④Vim tias qhov kawg ntim hauv thaj chaw kho mob ntau dua li qhov ntim ntawm Ellansé txhaj, tsis tas yuav tsum tau 'kov' kev kho mob
a) Qhov kawg ntim ntau dua qhov ntim ntawm 20-30% vim yog tsim ntawm collagen hom I fibers11
⑤ Qhov muaj ob hom ntawm REJEON nrog lub sijhawm sib txawv ntawm kev ua haujlwm txhais tau hais tias qhov ntev ntawm kev kho mob tuaj yeem raug kho raws li tus neeg mob.
kev xav tau
a) Qhov no ua tiav los ntawm qhov sib txawv ntawm qhov ntev ntawm PCL chains, tso cai rau kev kwv yees, tswj tau thiab kho tau bioresorption
⑥ Cov txheej txheem kev kho mob yog tib yam tsis hais cov khoom REJEON xaiv a) Tib yam:
● Rheological zog
● Cov txheej txheem
● Lub koob txhaj tshuaj
● Koob/cannula
REJEON PCL Unique muaj pes tsawg leeg
REJEON PCL yog tsim los ntawm ib qho tshwj xeeb, patented
kev sib xyaw ntawm:
● 7 0% carboxymethyl cellulose (CMC) - raws li gel carrier
● 3 0% polycaprolactone (PCL) microspheres (Daim duab 1 .4) 3, 4, 5
PCL microspheres tau tuav hauv
homogeneous suspension nyob rau hauv CMC-raws li gel carrier. PCL thiab CMC ob leeg muaj qhov zoo tshaj plaws thiab pov thawj biocompatibility profile.
REJEON PCL raw cov ntaub ntawv los ntawm Gemany
PCL MICROSPHERES
PCL yog polyester kho mob tsis muaj tshuaj lom, thawj zaug synthesized thaum ntxov 1930s4, uas yog
txaus nyiam siv nyob rau hauv dermal fillers vim nws yooj yim ntawm bioresorption; Nws yog ib txwm hydrolysed rau hauv carbon dioxide thiab dej hauv lub cev 5.
PCL microspheres siv nyob rau hauv
RE JEON yog tsim los muab
zoo biocompatibility6. Lawv muaj ib tug du nto, a
spherical puab thiab ib tug loj ntawm
kwv yees li 25-50 μm
PCL muaj qhov zoo tshaj plaws kev nyab xeeb profile3 thiab tau siv nyob rau hauv biomedical teb rau ntau tshaj 70 xyoo rau ntau yam kev siv, los ntawm sutures mus rau cov ntaub so ntswg thiab lub cev hloov los ntawm 3D luam ntawv (Daim duab 1.6)4. Nws kuj yog siv hauv CE-cim thiab US Food thiab
Kev Tswj Xyuas Tshuaj (FDA) - cov khoom pom zoo.
PROPERTIES NTAWM CMC
CMC yog cov khoom siv ntuj tsim los ntawm cellulose; nws tsis yog kev sib txuas, thiab tsis muaj tshuaj lom. Nws lwm yam khoom muaj xws li (Daim duab 1.7) 4:
● Nws yog ib qho tshuaj uas tau lees paub
● Nws yog hygroscopic
● Nws tau raug xaiv los ntawm FDA raws li feem ntau lees paub tias muaj kev nyab xeeb (GRAS)
● Resorption tshwm sim hauv 2 - 3 lub hlis
Cov txiaj ntsig tseem ceeb ntawm REJEON PCL Filler
REJEON PCL muaj qhov tshwj xeeb thiab zoo meej microsphere, nrog rau qhov loj me uas ua tau raws li cov qauv kev nyab xeeb thoob ntiaj teb thiab lub ntsej muag du uas tuaj yeem txuas ntxiv txhawb kev loj hlob ntawm collagen.
Collagen stimulation los ntawm REJEON: Cov pov thawj tshawb fawb
REJEON tau ua
kuaj nyob rau hauv ib tug tsiaj
qauv qhov twg luav tau txhaj nrog
los yog REJEON S
(PCL-1) lossis REJEON M (PCL-2) los tshawb xyuas neocollagenesis5 .
Cuaj hlis tom qab txhaj tshuaj PCL-1,
neocollagenesis tau tshwm sim thiab PCL microspheres ntawm PCL-1 tau raug tshem tawm tag nrho (Daim duab 1. 1 1) 5 .
Meanwhile, nrog PCL-2 ntawm 9 lub hlis,
muaj pov thawj ntawm kev tsim ntawm
hom I thiab hom III collagen nyob ib ncig ntawm
PCL microspheres. Thaum 2 1 lub hlis tom qab txhaj tshuaj, PCL- 2 microspheres tseem nyob hauv cov ntaub so ntswg 5.
Hauv kev tshawb nrhiav RE JEO N hauv tib neeg, cov neeg mob tau sau npe kom tau txais Ellansé txhaj tshuaj intradermally rau hauv lub tuam tsev
thaj 9. Histological tsom xam ntawm cov ntaub so ntswg tau los ntawm biopsies qhia
collagen tsim nyob ib ncig ntawm qhov txhaj tshuaj PCL hais (Daim duab 1 . 12) 9, txhawb kev tshawb pom zoo sib xws yav dhau los qhia hauv
luj 5.
REJEON mechanism ntawm kev txiav txim
REJEON muaj ob theem ntawm kev ua haujlwm (Daim duab 1.9) 1,4 :
● Kauj Ruam 1: Tam sim ntawd tom qab txhaj tshuaj, CMC tivthaiv muab ntim ib ntus,
uas maj mam txo qis dua 2-3 lub hlis
● Kauj Ruam 2: PCL microspheres induce
neocollagenesis ntawm hom I thiab III collagen, nrog ntau hom I collagen
qauv maj mam nce ntau dua 1 - 3 lub hlis thiab PCL microspheres
ua embedded nyob rau hauv hom I collagen
scaffold. Lub resulting collagen ntim
hloov qhov pib ntim nce los ntawm CMC gel
Lub collagen scaffold stimulated los ntawm PCL
microspheres tseem nyob tom qab lawv tau resorbed, ua rau lub ntim ruaj khov pom nrog REJEON
REJEON PCL Filler muaj cov txiaj ntsig zoo
REJEON PCL Filler yog lub siab-kawg ntev-ntev filling tus neeg sawv cev uas tuaj yeem tshem tawm cov kab laug sab laug los ntawm lub sijhawm thiab rov ua kom lub ntsej muag zoo nkauj thiab hluas rau lub ntsej muag.
REJEON PCL FILLER Cov neeg siv khoom pom zoo
Peb npaj siab los qhia peb cov kws tshaj lij thiab
paub txog thaum twg thiab yuav ua li cas koom nrog r ej eon hauv kev kho mob. Kuv vam tias nws yuav muaj txiaj ntsig zoo rau cov neeg nyeem ib yam li nws tau ua haujlwm rau kuv rau 10 xyoo dhau los: muab kev kho mob zoo dua nrog cov txiaj ntsig zoo dua thiab tau txais txiaj ntsig ntev. RE JEON yog ib qho cuab yeej tseem ceeb hauv kuv qhov kev coj ua thiab tau ua rau kuv tus neeg txhaj tshuaj zoo dua! ”
Dr Francisco de Melo
Plastic Surgeon, UAE
“RE JEON yog qhov kuv nyiam dermal muab tub lim rau
7 xyoo. Phau ntawv no yuav pab tau koj kom paub txog kev siv
RE JEON thiab koj yuav poob rau hauv kev hlub nrog nws. ”
Dr Li Lin
Dermatologist, Taiwan
“Kev txhim kho hauv cov qauv thiab daim tawv nqaij
zoo tshwm sim los ntawm RE JOE N's tshwj xeeb
neocollagenesis tsis sib haum. Undoubtedly yog ib qho ntawm cov cuab yeej zoo tshaj plaws rau cov chaw kho mob uas xav tau kev ua tau zoo tshaj plaws thiab kev nyab xeeb hauv cov khoom txhaj tshuaj. REJ EO N has the
muaj peev xwm muab kev nqa ntev ntev thiab txhim kho lub ntsej muag nrog ib zaug xwb. ”
Dr Ingrid Ló pez- Gehrke
Dermatologist, Mexico
“Kuv zoo siab heev rau kev siv RE JEON vim nws txoj kev hu nkauj zoo kawg nkaus. Qhov no tso cai tsawg dua
cov khoom yuav tsum tau siv, thiab los ntawm qhov tseeb zus tau tej cov collagen hom I, muaj peev xwm tiag tiag rau ntawm daim tawv nqaij
kev tsim kho dua tshiab. Ntau tus neeg mob qhia kuv tias: 'Nws yog thawj zaug
Kuv muaj ib yam dab tsi uas kav ntev', lossis 'Saib qhov zoo ntawm kuv daim tawv nqaij'. Tiag tiag kuv nyiam muab tub lim. ”
Dr Pierre Nicolau
Plastic Surgeon, Spain
REJEON MAJOR MILESTONES
Ua raws li kev tshawb fawb thiab kev loj hlob, thiab kev kho mob
kev sim, REJEON tau txais ISO 13485 Kev Tswj Xyuas Kev Tswj Xyuas Zoo hauv
20081 (Daim duab 1.2). Xyoo 2009, European Conformity (CE) tau pom zoo
tso cai, coj
mus rau qhov ua tau zoo tshaj tawm ntawm
cov khoom nyob rau hauv UK, Lub teb chaws Yelemees thiab Spain. Lwm qhov kev xa tawm ua raws, nrog rau npe hauv ntau dua 69
lub teb chaws los ntawm 2018. Los ntawm 2019, lub
10-xyoo hnub tseem ceeb ntawm rejeon, ntau dua
tau muag ntau tshaj 1 lab koob txhaj tshuaj
thoob ntiaj teb. Tab sis zaj dab neeg ua tiav tsis tau tso tseg, nrog rau qhov chaw tsim khoom tshiab hauv Netherlands pib
production hauv 2020
REJEON PCL Cov Khoom Muag Khoom Muag
1 ml / pcs
Txais OEM customized ntim
